Twin explosions strike southern Syrian city

BEIRUT (AP) — Syria‘s state-run news agency says two large explosions have struck the southern city of Daraa, causing multiple casualties and heavy material damage.

SANA did not immediately give further information or say what the target of Saturday’s explosions was.

The Britain-based Syrian Observatory for Human Rights says the blasts went off near a branch of the country’s Military Intelligence in Daraa.

The Observatory, which relies on a network of activists on the ground, says the explosions were followed by clashes between regime forces and rebels fighting to topple President Bashar Assad.

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Taiwan’s HTC settles patent disputes with Apple

TAIPEI, Taiwan (AP) — Taiwanese smartphone maker HTC Corp. has settled with Apple Inc. on their outstanding patent disputes.

In a joint statement Sunday, the two companies said they also signed a 10-year license agreement that will extend to current and future patents held by one other.

Apple and HTC had battled patents over various smartphone features since March 2010, with the Cupertino-based firm accusing HTC phones that run on Google‘s Android software of infringing on its patents.

HTC chief executive Peter Chou says ending the litigation will allow his company to focus more on product innovation.

HTC has grown as the first maker of phones running on Android software. But its sales faltered from the second half of 2011 in a market increasingly divided between Apple and Samsung Electronics Co.

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Is “Our Kind of Traitor” next for Mads Mikkelsen?

LOS ANGELES (TheWrap.com) – Since winning the Best Actor award at this year’s Cannes Film Festival for Thomas Vinterberg‘s “The Hunt,” Mads Mikkelsen has been inundated with offers for new projects.

Mikkelson, who also stars in Denmark’s entry for the foreign Oscars, “A Royal Affair,” has yet to decide what he will do next, according to his representatives. But one of his choices, they say, is “Our Kind of Traitor,” the film adaptation of the John le Carre spy novel.

“Our Kind of Traitor, is being put together by a consortium of British producers, including Film4, Potboiler Productions and The Ink Factory.

It will be directed by Justin Kurzel from a screenplay by Hossein Amini. It tells the story of a young English couple who bond with a millionaire Russian businessman after a chance encounter on vacation.

What they don’t know is that the enigmatic Russian is a money launderer seeking to defect to British intelligence before his rivals have a chance to murder him. He has chosen the couple as his lifeline.

The couple’s recruitment by the secret service is followed by a deadly chase, which takes them from the souks of Marrakesh to London, to the French Open Tennis Final in Paris and to a thrilling climax in the Swiss Alps.

Ralph Fiennes name has also come up with the project, as has Jessica Chastain‘s, although a rep for the actress says she has yet to receive an offer.

Mikkelsen has lately been busy in Canada filming his role as Dr. Hannibal Lecter, which U.S. writer-producer Bryan Fuller has reinvented for a 13-episode NBC-Gaumont television series, “Hannibal.”

Mikkelsen, who got his break in Danish director Nicolas Winding Refn‘s “Pusher” in 1996, has notched up a number of high-profile credits, including the role of the villain Le Chiffre in the James Bond movie, “Casino Royale.” He also played the composer in “Coco Chanel & Igor Stravinsky,” and could be seen in “Clash of The Titans” and “The Three Musketeers.”

This summer he filmed Fredrik Bond’s “The Necessary Death of Charlie Countryman,” with Shia LaBeouf and Evan Rachel Wood, and Danish director Asger Leth’s “Move On.” The Danish film powerhouse, TrustNordisk is also working on a new project for the actor to film next summer but said that it is keeping the details closely under wraps.

His other upcoming films include the French period piece “Michael Kohlhaas,” which tells the story of a well-to-do horse merchant, and an adventure-western called “The Stolen.”

The Ink Factory and Potboiler Productions did not return calls to TheWrap for comment on the casting for “Our Kind of Traitor.”

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Boehringer Ingelheim to start late-stage hepatitis C drug trial

BOSTON (Reuters) – Boehringer Ingelheim said on Saturday it plans to initiate a late-stage clinical trial of its experimental hepatitis C treatment following promising results from earlier studies.

The company announced final data from a mid-stage trial of its treatment regimen which showed that 69 percent of patients in the study were free of the virus 12 and 24 weeks following the end of treatment.

Hepatitis C is a blood-borne infectious disease of the liver that can lead to liver failure and transplant.

Historically, hepatitis C has been treated with pegylated interferon and ribavirin, but treatment lasts as long as 48 weeks and interferon is associated with flu-like side effects.

The goal of drugmakers now, including Boehringer, Vertex Pharmaceuticals Inc, Gilead Sciences Inc and Bristol-Myers Squibb Co is to develop products that do not need to be combined with interferon. Most analysts consider Gilead to currently be at the forefront of the race.

Full results from Boehringer’s trial, known as SOUND-C2, were presented at the annual meeting of the American Association for the Study of Liver Diseases in Boston. Preliminary data were presented earlier this year.

Boehringer’s trial tested a combination of BI-201335, a protease inhibitor, BI-207127, a polymerase inhibitor, and ribivirin.

Boehringer is a privately held company headquartered in Ingelheim, Germany.

(Reporting By Toni Clarke; Editing by Marguerita Choy)

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Obama Hangs Tough on the Fiscal Cliff

President Barack Obama made clear today that he plans to take a tough line in budget negotiations with congressional Republicans. That pretty much assures that there will be no deal soon and we’ll be hearing about the “fiscal cliff” of automatic spending cuts and scheduled tax hikes long past Jan. 1.

The fiscal cliff is scheduled to be reached at the start of 2013. But the most likely outcome now is that the parties will come up with a patch—a temporary agreement to postpone the effects of the fiscal cliff while negotiations continue. That will keep the economy from suffering an immediate blow, but it will also mean continued uncertainty, which discourages consumers from spending and businesses from investing.

Tired of hearing about the fiscal cliff now? Wait until next summer, when it could still be a topic of daily conversation inside the Beltway. On the eve of the election, Representative James Clyburn of South Carolina, the third-ranking House Democrat, told Fox News Channel’s Neil Cavuto that a patch could last “up to, maybe, around a year.”

In a speech in the White House East Room, Obama said the election showed that “a majority of Americans agree with my approach.”

Obama wants to end the Bush tax cuts on household income above $ 200,000 a year (individuals) or $ 250,000 a year (couples). That will affect just 2 percent of Americans. Republicans want to preserve all of the Bush tax cuts, including for the highest-income Americans. In a gambit to put the Republicans in a politically difficult position, Obama called on Congress to extend the Bush tax cuts for people earning under $ 250,000 a year while negotiations continue on the top brackets. “We shouldn’t need long negotiations or drama,” he said.

House Speaker John Boehner said Nov. 8 that GOP leaders were open to increasing revenue, but by closing deductions and credits, not by raising tax rates, which they continue to oppose. Boehner also said any revenue increase should come as part of a package that overhauls entitlement spending and the tax code.

Obama said he was inviting congressional leaders of both parties to the White House next week for talks.

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Syria opposition bloc elects Christian as leader

DOHA, Qatar (AP) — Syria‘s main opposition group in exile has elected a Christian Paris-based former geography teacher as its new president.

George Sabra said Friday that his election as head of the Syrian National Council is a sign that the opposition is not plagued by sectarian divisions.

Sabra says the SNC‘s main demand is to receive weapons from the international community. The U.S. and some other foreign backers of rebels fighting the regime of President Bashar Assad have so far refused to send weapons for fear they can fall into the wrong hands.

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Walmart Moves Up Black Friday

Walmart is kicking off Black Friday shopping earlier than ever this year, opening stores at 8 p.m. on Thanksgiving Day.

“In addition to offering amazing low prices on the season’s top gifts, Walmart is taking the historic step to ensure wishlist items like the Apple iPad2 are available for customers during a special one-hour event on Thanksgiving,” the world’s largest retailer said in a statement today.

“We know it’s frustrating for customers to shop on Black Friday and not get the items they want,” said Duncan Mac Naughton, chief merchandising and marketing officer, Walmart U.S. “This year, for the first time ever, customers that shop during Walmart’s one-hour event will be guaranteed to have three of the most popular items under their tree at a great low price.”

Other retailers will also be opening earlier, including Sears at 8 p.m. on Thanksgiving, moved up from 4 a.m. on Black Friday last year. Kmart will be open Thanksgiving Day 6 a.m. to 4 p.m., then it will close and reopen 8 p.m. to 3 a.m. Macy’s, Kohl’s and Best Buy open at midnight; Toys R Us hasn’t announced its plans. Advice on how to snag the best deals.

To help convince folks to head out to the store after dinner, Walmart said it will guarantee that customers who are inside the store and in line between 10 p.m. and 11 p.m. can get these deals:

Apple iPad ®2 16GB with Wi-Fi – $ 399 plus get a $ 75 Walmart Gift Card

Emerson ® 32 720p LCD TV – $ 148

LG ® Blu-ray™ Player – $ 38

“If any of these items happen to sell out before 11 p.m. local time, Walmart will offer a Guarantee Card for the item which must be paid for by midnight and registered online. The product will then be shipped to the store where it was purchased for the customer to pick up before Christmas,” the retailer said.

A few of the top items available in store, while supplies last, include:

8 p.m. on November 22: Gifts for the Entire Family – Toys, Gaming, Home and Apparel

Xbox 360 ® 4GB + SkyLanders ™ Bundle – $ 149

Wii ™ Console- $ 89

More than 100 video games priced at $ 10, $ 15 or $ 25 each

Top Toys of the Season: Leappad ® 1.0 Learning Tablet ($ 65) and Furby ® ($ 45)

Razor ® Accelerator 12-Volt Electric Scooter – $ 79

Fisher Price Power Wheels ® Jeep ® Wrangler 6-Volt Ride Ons (Hot Wheels ® and Barbie ®) – $ 89 each

Licensed Boys’ and Girls’ 2-Piece Sleep Set – $ 4.50 each

Mens and Ladies Denim – $ 9.50 each

Home appliances such as a Crock Pot ® 6-Quart Slow Cooker and Mr. Coffee ® Programmable 12-Cup Coffee Maker – $ 9.44 each

Shark ® Steam Pocket Mop and Ninja ® Pulse Blender – $ 39 each

Fashion Dolls such as Barbie ®, Bratz ™ and Disney ® Princess – $ 5 each

Hundreds of DVD and Blu-ray movies such as Brave, The Amazing Spiderman, Hunger Game ranging from $ 1.96 to $ 9.96 each

Better Homes and Gardens ® 700-Thread Count Sheet Set – $ 19.96

48″ Air-Powered Hockey Table – $ 29.86

14′ Trampoline with Enclosure and Bonus Flash Light Zone – $ 159

10 p.m. on November 22: The BIG Event – Brand Name Electronics

Vizio ® 60″ 720p LED Smart TV with built in Wi-Fi – $ 688

Samsung ® 43″ 720p 600Hz Class Plasma HDTV – $ 378

HP ® 15.6″ Laptop with 4GB and 320GB hard drive – $ 279

Nikon ® D3000 Digital Camera with Lens Kit – $ 449

Samsung ® Smart ST195 Digital Camera – $ 99

Beats by Dr. Dre ® Headphones – $ 179.95

Nook ® Color ™ 8GB Tablet – $ 99

Virgin Mobile ® 3G/4G Hotspot – $ 39.88

5 a.m. on Nov. 23: Caffeine Not Needed – Great Savings on Gifts from Jewelry to Tires

Sharp ® 70″ 1080p 120Hz HDTV – $ 1,798

Acer ® 13.3″ Ultrabook ™ with 4GB and 320GB solid state drive – $ 499

$ 100 Walmart gift card with the purchase of select smartphones such as the Samsung ® Galaxy S III, Droid RAZR M by Motorola ® and HTC ® One X

Goodyear Tires ranging from $ 59 – $ 99 each

Forever Bride 1/3 -Carat T.W. Diamond Ring in 10K Gold – $ 198

Stanley ® 6-Drawer Rolling Tool Cabinet with 85-Piece Mechanic Tool Set – $ 99

Singer ® Sew Mate 5400 60-Stitch Sewing Machine – $ 99.97

5? Pre-Lit Harrison Christmas Tree – $ 20

Better Homes and Gardens Deluxe Recliner – $ 199

Black Friday Specials & More Online:

Samsung 50″ Class LED 1080p 60Hz HDTV – $ 698

Ematic 7″ Tablet Android 4.0 1GHz, 4GB – $ 49

Dsi XL Ultimate Bundle – $ 129

Razor A Kick Scooter, Multiple Colors – $ 25

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“Lincoln” Reviews: Is Steven Spielberg’s biopic Oscar-worthy?

LOS ANGELES (TheWrap.com) – “Lincoln,” with a cast of acting titans like Daniel Day-Lewis and Tommy Lee Jones, arrives in theaters Friday with many predicting big things come Oscar night. But does Steven Spielberg‘s biopic of the Great Emancipator live up to the early hype?

Based on initial reviews, it seems like Spielberg and company have delivered. Critics are raving about Day-Lewis’ performance and crediting the film with taking a historical figure who is cloaked in myth and making him relatable and sympathetically human. Instead of uncoiling a birth-through-death chronology of Father Abraham, “Lincoln” narrows its gaze to a few key months in 1865 when the president was trying to simultaneously end the Civil War and pass an amendment abolishing slavery.

The film, which will expand nationally next week after opening in limited release this weekend, scored a bullish 92 percent “fresh” rating on critics aggregator Rotten Tomatoes.

In TheWrap, Alonso Duralde lavished praise on the film and its literate script from Pulitzer Prize winner Tony Kushner for finding the man behind the monument. His one bone of contention was not with the film itself but with its gauzy ad campaign.

“The dreadful trailer makes ‘Lincoln‘ look like an awful collection of Spielbergian excesses, including swelling John Williams moments (admittedly, there are one or two) and Janusz Kaminski’s honey-baked lighting (OK, granted, it appears, but not too often), not to mention Tommy Lee Jones‘ terrible wig (which actually winds up being organic in his memorable turn as Thaddeus Stevens),” Duralde writes. “Don’t let the marketing campaign keep you from seeing one of the best American movies this year, and Spielberg’s finest work in decades.”

Perhaps no critical enthusiasm could match that of A.O. Scott. In a glowing review in The New York Times, Scott sounds the trumpets for Spielberg’s epic, urging parents to bundle their children into the local multiplex to see history unfurl across the screen.

“Some of the ambition of ‘Lincoln‘ seems to be to answer the omissions and distortions of the cinematic past, represented by great films like D. W. Griffith‘s ‘Birth of a Nation,’ which glorified the violent disenfranchisement of African-Americans as a heroic second founding, and ‘Gone With the Wind,’ with its romantic view of the old South,” Scott writes. “To paraphrase what Woodrow Wilson said of Griffith, Mr. Spielberg writes history with lightning.”

For Kenneth Turan, the greatness of the film lies in its understatedness. Writing in the Los Angeles Times, he lauded Spielberg for abandoning his more bombastic impulses to focus on the interior life of an American president.

“There is nothing bravura or overly emotional about Spielberg’s direction here, but the impeccable filmmaking is no less impressive for being quiet and to the point,” Turan writes. “The director delivers selfless, pulled-back satisfactions: he’s there in service of the script and the acting, to enhance the spoken word rather than burnish his reputation.”

It’s an “A,” declares Entertainment Weekly’s Owen Gleiberman, who hails the film for getting its hands dirty while depicting the sausage-making of politics.

“The Lincoln we see here is that rare movie creature, a heroic thinker,” he writes. “He has the serpentine intellect of a master lawyer, infused with a poet’s passion. ‘Lincoln’ brilliantly dramatizes the delicacy of politics, along with the raw brutality of it.”

In New York magazine, David Edelstein savored the film, but admitted that a few moments could have gone down more smoothly. In particular, he said the film’s initial scenes suffered from musty dialogue and some of the political wrangling it depicted was difficult to follow. Ultimately, however, he credited the picture with finding a fresh take on a president whose legacy has been dissected and debated for generations.

“By the time the movie ends, you don’t feel as if you know Lincoln – few, in his own time, claimed to know him,” Edelstein writes. “But you feel as if you know what it was like to be in his presence. And so an icon (it’s a measure of how promiscuously that word is thrown around that it seems inadequate for one of history’s truly iconic figures) has become a man – and, startlingly, within reach.”

There were a few critics, of course, who were not ready to endorse “Lincoln.” In the Newark Star-Ledger, Stephen Whitty slammed the movie for choking on its own self-serious and mocked it for too many scenes of intense debates held by men with copious facial hair.

“So if you’ve been sitting around wondering, ‘Gee, when is Spielberg ever going to make another ‘Amistad?’ ’ here’s your answer,” Whitty writes.

Apparently, Whitty would prefer another “Jaws.”

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California teen steps into rattlesnake nest, survives

SAN DIEGO (Reuters) – A teenage California girl searching for a cell phone signal to call her mother in a rural area outside San Diego inadvertently stepped into a nest of rattlesnakes and was bitten six times, but survived.

The 16-year-old, Vera Oliphant, spent four days in the intensive care unit of Sharp Grossmont Hospital, and doctors gave her 24 vials of antivenom after she was bitten by an adult rattlesnake and five young rattlers outside her uncle’s home.

“I was trying to find a signal to call my mom and text my boyfriend,” Oliphant said on Friday, a day after she was released from the hospital following the October 27 incident.

“I didn’t see them until I already stepped on their nest and I felt them biting me.”

“My vision started to go right away. First it looked like the snakes blended into the leaves and then I started seeing black spots around the edges and I started blacking out.”

She returned to her uncle’s home in Jamul, outside San Diego, and he immediately packed her into the car and rushed her to the emergency room, she said.

On the way, she talked to her mom and her boyfriend, who told her to stay calm so the venom wouldn’t spread.

“I told my mom and my boyfriend I love them in case I don’t get to see them again,” she said.

Doctors there administered 24 vials of antivenom to quash the dangerous toxins, according to a hospital spokesman. Snakebites usually aren’t fatal, although a handful of people die in the United States each year from snake bites, including bites from rattlesnakes.

Oliphant has recovered and will be returning to classes at Chaparral High School in El Cajon on Monday. She said the next time she can’t get a signal, she will handle it differently.

“Be careful where you step,” she said. “If you don’t need to, just wait until you are somewhere that you can call people.”

(Editing By Cynthia Johnston and Todd Eastham)

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Myanmar says Obama to visit later this month

YANGON, Myanmar (AP) — President Barack Obama will make a groundbreaking visit later this month to Myanmar, an official said Thursday, following through with his policy of rapprochement to encourage democracy in the Southeast Asian nation.

The Myanmar official speaking from the capital, Naypyitaw, said Thursday that security for a visit on Nov. 18 or 19 had been prepared, but the schedule was not final. He asked not to be named because he was not authorized to give information to the media.

The official said Obama would meet with opposition leader Aung San Suu Kyi as well as government officials including reformist President Thein Sein.

It would be the first-ever visit to Myanmar by an American president. U.S. officials have not yet announced any plans for a visit, which would come less than two weeks after Obama’s election to a second term.

Obama’s administration has sought to encourage the recent democratic progress under Thein Sein by easing sanctions applied against Myanmar’s previous military regime.

Officials in nearby Thailand and Cambodia have already informally announced plans for visits by Obama that same week. Cambodia is hosting a summit meeting of the Association of Southeast Asian Nations, and Thailand is a longtime close U.S. ally.

The visit to Myanmar, also known as Burma, would be the culmination of a dramatic turnaround in relations with Washington as the country has shifted from five decades of ruinous military rule and shaken off the pariah status it had earned through its bloody suppression of democracy.

Obama’s ending of the long-standing U.S. isolation of Myanmar’s generals has played a part in coaxing them into political reforms that have unfolded with surprising speed in the past year. The U.S. has appointed a full ambassador and suspended sanctions to reward Myanmar for political prisoner releases and the election of Nobel laureate Suu Kyi to parliament.

From Myanmar’s point of view, the lifting of sanctions is essential for boosting a lagging economy that was hurt not only by sanctions that curbed exports and foreign investment, but also by what had been a protectionist, centralized approach. Thein Sein’s government has initiated major economic reforms in addition to political ones.

A procession of senior diplomats and world leaders have traveled to Myanmar, stopping both in the remote, opulent capital city, which was built by the former ruling junta, and at Suu Kyi’s dilapidated lakeside villa in the main city of Yangon, where she spent 15 years under house arrest. New Zealand announced Thursday that Prime Minister John Key would visit Myanmar after attending the regional meetings in Cambodia.

The most senior U.S. official to visit was Hillary Rodham Clinton, who last December became the first U.S. secretary of state to travel to Myanmar in 56 years.

The Obama administration regards the political changes in Myanmar as a marquee achievement in its foreign policy, and one that could dilute the influence of China in a country that has a strategic location between South and Southeast Asia, regions of growing economic importance.

But exiled Myanmar activists and human rights groups are likely to criticize an Obama visit as premature, rewarding Thein Sein before his political and economic reforms have truly taken root. The military — still dominant and implicated in rights abuses — has failed to prevent vicious outbreaks of communal violence in the west of the country that have left scores dead.

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